Full Material List

dimethyl fumarate


Material Info

FEMA N/A
CAS 624-49-7
EINECS 210-849-0
JECFA Food Flavoring N/A
CoE Number N/A
Organoleptic Notes
  • Odor and/or flavor descriptions from others (if found).
Odor N/A
Flavor N/A
Material Notes Fungal growth inhibitor for tomato juice

Dimethyl fumarate is an ester and an ?,?-unsaturated electrophilic compound, undergoing reactions typical to them. It is also a diene acceptor in the ordinary Diels-Alder reaction, where the reactivity of its vinylidenic bond is enchanced by the two electron-withdrawing ester groups. Due to the geometry of the starting ester, the Diels-Alder product will have a trans configuration.; Dimethyl fumarate is used to treat psoriasis.. It is a lipophilic, highly mobile molecule in human tissue. However, as an ?,?-unsaturated ester, dimethyl fumarate reacts rapidly with the detoxifying agent glutathione by Michael addition. When administered orally, it does not survive long enough to be absorbed into blood.

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