FlavScents AInsights Entry for Cyclohexyl Ethyl Acetate (CAS: 21722-83-8)

1. Identity & Chemical Information

• Common Name(s): Cyclohexyl ethyl acetate
• IUPAC Name: Ethyl cyclohexylacetate
• CAS Number: 21722-83-8
• FEMA Number: Not available
• Other Identifiers: Not available
• Molecular Formula: C10H18O2
• Molecular Weight: 170.25 g/mol

Cyclohexyl ethyl acetate is an ester characterized by the presence of an acetate group linked to a cyclohexyl ring. This structure contributes to its fruity and floral odor profile, which is relevant in both flavor and fragrance applications. The ester functional group is known for imparting sweet, fruity notes, often used to enhance the sensory appeal of products.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Cyclohexyl ethyl acetate is noted for its pleasant, fruity, and floral aroma, reminiscent of apple and pear with subtle green nuances. It is often described as having a moderate intensity and good diffusion, making it suitable for use as an impact note in both flavors and fragrances. The compound's odor threshold is not well-documented, but its sensory role typically involves adding a fresh, sweet character to formulations.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Cyclohexyl ethyl acetate is not commonly found in nature and is primarily synthesized for use in industrial applications. Its formation typically involves the esterification of cyclohexanol with acetic acid or acetic anhydride. Due to its synthetic origin, it does not qualify for "natural flavor" or "natural fragrance" designations under most regulatory frameworks.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Cyclohexyl ethyl acetate is utilized in various flavor categories, including fruit, confectionery, and beverage applications. It serves as a functional component to enhance fruity notes and provide a fresh, sweet background. Typical use levels in finished products range from 1 to 10 ppm, with higher concentrations potentially leading to overpowering effects. The compound is generally stable under typical food processing conditions, though it may degrade under extreme heat or acidic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance formulations, cyclohexyl ethyl acetate is employed across multiple fragrance families, such as floral, fruity, and green. It acts as a modifier or impact note, contributing to the top and middle notes of a fragrance composition. Typical concentration ranges in perfumes and personal care products are from 0.1% to 1%, depending on the desired intensity and product type. Its volatility allows it to impart a fresh, uplifting aroma upon application.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Cyclohexyl ethyl acetate is not explicitly listed as FEMA GRAS but is used in compliance with general safety standards.
• European Union: Not specifically listed under Regulation (EC) No 1334/2008; usage is subject to general safety assessments.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Limited specific data; usage typically aligns with international safety standards.
• Latin America: Usage is generally harmonized with international practices, though specific approvals may vary.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Data not found for specific ADI or MSDI values; usage in flavors is generally considered safe at typical concentrations.
• Dermal Exposure: No significant irritation or sensitization reported; aligns with IFRA guidelines for fragrance use.
• Inhalation Exposure: Volatility suggests potential for inhalation exposure, but no specific occupational hazards identified.

Overall, cyclohexyl ethyl acetate is considered safe for use in both food and fragrance applications when used within recommended guidelines.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Cyclohexyl ethyl acetate is valued for its ability to impart a fresh, fruity character to both flavors and fragrances. It synergizes well with other fruity and floral notes, enhancing the overall complexity of a formulation. Formulators should be cautious of its potential to dominate a blend if used excessively, and it is often underutilized in applications seeking a subtle, natural fruitiness.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on cyclohexyl ethyl acetate is well-established in terms of its sensory profile and general safety. However, specific regulatory approvals and detailed toxicological data are less documented, reflecting industry-typical practices rather than explicit regulatory guidance.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-03-04 12:07:38 GMT (p2)