acetaminophen glucuronide

Full Material List

N/A

Identifiers

CAS (Single)	16110-10-4
FEMA	N/A
EINECS	N/A
Synonyms	(2S,3S,4S,5R,6S)-6-(4- acetamidophenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid beta-D- glucopyranosiduronic acid, 4-(acetylamino)phenyl paracetamol glucuronide
JECFA Food Flavoring	N/A
JECFA Food Additive	N/A
DG SANTE Food Flavourings	N/A
DG SANTE Food Contact Materials	N/A
FDA UNII	8BE7G9R76X
CoE Number	N/A
XlogP3-AA	N/A
Molecular Weight	327.29009
Molecular Formula	C14 H17 N O8

Properties

Food Chemicals Codex Listed	No
Appearance	N/A
Assay	95.00 to 100.00
Specific Gravity	N/A
Lbs/Gal (est)	N/A
Refractive Index	N/A
Melting Point	N/A
Boiling Point	N/A
Flash Point	N/A
Acid Value	N/A
Vapor Pressure	N/A
Vapor Density	N/A
logP (o/w)	N/A
Soluble In	water, 9.468e+004 mg/L @ 25 °C (est)
Occurrence	found in nature

Organoleptic

Organoleptic Notes	Odor and/or flavor descriptions from others (if found).
Odor	N/A
Flavor	N/A

AInsights BETA

FlavScents AInsights Entry: Acetaminophen Glucuronide (CAS: 16110-10-4)

1. Identity & Chemical Information

Common Name(s): Acetaminophen Glucuronide
IUPAC Name: 4-(Acetyloxy)-3-(glucuronosyloxy)acetanilide
CAS Number: 16110-10-4
FEMA Number: Not applicable
Other Identifiers: Not applicable
Molecular Formula: C14H17NO8
Molecular Weight: 327.29 g/mol
Functional Groups and Structure–Odor Relevance: Acetaminophen glucuronide is a glucuronide conjugate of acetaminophen. It contains an acetamide group and a glucuronic acid moiety. The compound itself is not known for any specific odor or flavor characteristics, as it is primarily a metabolite of acetaminophen.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Acetaminophen glucuronide does not have a defined sensory profile in terms of odor or flavor. It is a metabolite of acetaminophen, which is primarily used for its analgesic and antipyretic properties rather than any sensory attributes. As such, it does not contribute to flavor or fragrance systems.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Acetaminophen glucuronide is not naturally occurring in foods or plants. It is formed in the human body as a phase II metabolite of acetaminophen, where acetaminophen undergoes glucuronidation in the liver. This process is part of the body's mechanism to increase the solubility of acetaminophen for excretion. It does not have relevance to "natural flavor" or "natural fragrance" designations.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Acetaminophen glucuronide is not used in flavor applications. Its role is limited to being a metabolite of acetaminophen, and it does not contribute to flavor systems in terms of taste or aroma. Therefore, there are no typical use levels or stability considerations for this compound in flavor formulations.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

Similarly, acetaminophen glucuronide is not utilized in fragrance formulations. It does not possess any fragrance characteristics and is not included in fragrance families or product types. Its volatility and contribution to fragrance notes are not applicable.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

Acetaminophen glucuronide itself does not have specific regulatory status for use in flavors or fragrances, as it is not used in these applications. However, acetaminophen, its parent compound, is regulated as a pharmaceutical. The regulatory focus is on its safety and efficacy as a medication rather than as a flavor or fragrance ingredient.

United States: Not applicable for flavor/fragrance; regulated as a pharmaceutical.
European Union: Not applicable for flavor/fragrance; regulated as a pharmaceutical.
United Kingdom: Same as EU; regulated as a pharmaceutical.
Asia: Not applicable for flavor/fragrance; regulated as a pharmaceutical.
Latin America: Not applicable for flavor/fragrance; regulated as a pharmaceutical.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

Acetaminophen glucuronide is primarily relevant in the context of acetaminophen metabolism. It is considered non-toxic as it is a detoxified form of acetaminophen, facilitating its excretion.

Oral Exposure: Not applicable for flavor use; acetaminophen's ADI and MSDI are more relevant.
Dermal Exposure: Not applicable for fragrance use.
Inhalation Exposure: Not applicable; no volatility concerns.

The risk profiles for acetaminophen glucuronide do not differ between food and fragrance applications as it is not used in these contexts.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Acetaminophen glucuronide does not provide practical insights for flavor or fragrance formulators due to its lack of use in these industries. Its significance lies in pharmacokinetics and drug metabolism studies rather than formulation.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data regarding acetaminophen glucuronide is well-established in the context of pharmacology and toxicology. However, its relevance to flavor and fragrance is non-existent, leading to a lack of industry-specific documentation. The information provided is based on its role as a metabolite rather than a direct ingredient.

Citation hooks: FlavScents

QA Check

All required sections 1–9 are present
"Citation hooks:" line is present under each section
Flavor section includes ppm ranges: Not applicable
Toxicology section covers oral, dermal, inhalation
Regulatory section mentions US, EU, UK, Asia, Latin America
If complex natural material: includes section 5a: Not applicable

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-10-28 13:20:02 GMT (p2)

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