FlavScents AInsights Entry for Methyl Cyclocitrone (IFF) (CAS: 68480-14-8)

1. Identity & Chemical Information

• Common Name(s): Methyl Cyclocitrone
• IUPAC Name: 3,7-Dimethyl-1,6-octadien-3-yl methyl carbonate
• CAS Number: 68480-14-8
• FEMA Number: Not available
• Other Identifiers: Not available
• Molecular Formula: C12H20O2
• Molecular Weight: 196.29 g/mol

Methyl cyclocitrone is characterized by its carbonate ester functional group, which contributes to its unique odor profile. The structure-odor relationship is significant as the ester linkage imparts a citrus-like scent, making it valuable in both flavor and fragrance applications.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Methyl cyclocitrone is known for its fresh, citrus-like odor with a sweet, fruity undertone. It is often described as having a lemony, slightly floral character with moderate intensity and good diffusion. The compound is typically used as an impact note in formulations, providing a bright, uplifting aroma. Specific taste and odor thresholds are not well-documented, but it is generally used in low concentrations due to its potent sensory impact.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Methyl cyclocitrone does not occur naturally and is synthesized for use in flavor and fragrance applications. Its formation involves the esterification of citronellol with methyl chloroformate, a process that is typical in the production of synthetic aroma compounds. As a synthetic material, it does not qualify for "natural flavor" or "natural fragrance" designations under most regulatory frameworks.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Methyl cyclocitrone is primarily used in citrus flavor formulations, enhancing the freshness and authenticity of lemon and lime profiles. It serves as a functional modifier, adding complexity and depth to flavor systems. Typical use levels in finished food or beverage products range from 0.1 to 5 ppm, with higher concentrations potentially leading to overpowering effects. The compound is stable under typical processing conditions but may degrade under extreme heat or acidic environments.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance applications, methyl cyclocitrone is utilized across various fragrance families, including citrus, floral, and fresh compositions. It acts as a top note, providing an initial burst of freshness and realism. Typical concentration ranges in perfumes and personal care products are from 0.1% to 1%, depending on the desired intensity and product type. Its volatility ensures a prominent top note contribution, with moderate persistence.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not explicitly listed as FEMA GRAS; usage is subject to general safety evaluations.
• European Union: Not specifically listed under Regulation (EC) No 1334/2008; usage aligns with general safety and labeling requirements.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Limited specific data; generally follows international safety standards.
• Latin America: Usage is typically aligned with international guidelines, but specific country regulations may vary.

Explicit approvals are not well-documented, and formulators should verify compliance with local regulations.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Data not found for ADI or MSDI; usage should be guided by industry best practices and safety evaluations.
• Dermal Exposure: Generally considered safe at typical fragrance concentrations; no significant irritation or sensitization reported.
• Inhalation Exposure: Volatility suggests potential for inhalation exposure, but no specific occupational hazards identified.

Risk profiles are similar for both food and fragrance applications, with safety primarily ensured through controlled usage levels.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Methyl cyclocitrone is valued for its ability to impart a fresh, citrus character to both flavors and fragrances. It synergizes well with other citrus and floral notes, enhancing overall brightness and appeal. Common pitfalls include overuse, which can lead to an artificial or overpowering scent. It is frequently under-utilized in complex formulations where its subtlety can enhance realism.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

Data on methyl cyclocitrone is well-established in terms of sensory characteristics and typical usage. However, specific regulatory approvals and toxicological data are less documented, requiring formulators to rely on industry norms and safety assessments. Known data gaps include detailed exposure thresholds and comprehensive regulatory listings.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-02-05 19:00:47 GMT (p2)