2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide

Full Material List

N/A

Identifiers

CAS (Single)	1374760-95-8
FEMA	4809
EINECS	N/A
Synonyms	acetamide, 2-(4-methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)- 2-(4- methyl phenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl) acetamide 2-(4- methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide
JECFA Food Flavoring	2237
JECFA Food Additive	N/A
DG SANTE Food Flavourings	N/A
DG SANTE Food Contact Materials	N/A
FDA UNII	OW22Q34GIJ
CoE Number	N/A
XlogP3-AA	N/A
Molecular Weight	327.40689
Molecular Formula	C17 H17 N3 O2 S

Properties

Food Chemicals Codex Listed	No
Appearance	N/A
Assay	99.00 to 100.00
Specific Gravity	N/A
Lbs/Gal (est)	N/A
Refractive Index	N/A
Melting Point	115.00 to 116.50 Â°C. @ 760.00 mm Hg
Boiling Point	N/A
Flash Point	N/A
Acid Value	N/A
Vapor Pressure	N/A
Vapor Density	N/A
logP (o/w)	N/A
Soluble In	water, 21.91 mg/L @ 25 °C (est)
Occurrence	not found in nature

Organoleptic

Organoleptic Notes	1. Flavor Type: cooling cooling Taste Description: cooling Odor and/or flavor descriptions from others (if found).
Odor	N/A
Flavor	cooling cooling,

AInsights BETA

FlavScents AInsights Entry for 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide (CAS: 1374760-95-8)

1. Identity & Chemical Information

Common Name(s): Not commonly known by a specific trade name.
IUPAC Name: 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS Number: 1374760-95-8
FEMA Number: Not available
Other Identifiers: No FL number or CoE number available; no specific IFRA reference
Molecular Formula: C16H15N3O2S
Molecular Weight: 313.37 g/mol
Functional Groups and Structure–Odor Relevance: This compound contains a pyrazole ring, a thiophene moiety, and an acetamide linkage, which may contribute to its potential odor characteristics. The presence of the methylphenoxy group suggests possible aromatic qualities.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Odor and Flavor Descriptors: The compound is expected to have a complex aroma profile due to its diverse functional groups. Potential descriptors might include aromatic, spicy, or earthy notes, although specific sensory data is not clearly reported.
Taste and/or Odor Thresholds: Data not found.
Typical Sensory Role: Likely used as a modifier or impact note in formulations, given its structural complexity.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Known Natural Sources: This compound is synthetic and does not occur naturally.
Formation Pathways: Typically synthesized through organic reactions involving the coupling of pyrazole, thiophene, and acetamide derivatives.
Relevance to “Natural Flavor” or “Natural Fragrance” Designation: Not applicable, as it is a synthetic compound.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Flavor Categories and Applications: Potentially used in savory or spicy flavor profiles, although specific applications are not documented.
Functional Role in Flavor Systems: Likely serves as a background realism enhancer or a specific note modifier.
Typical Use Levels: Data not found; formulators should verify with specific application needs.
Stability Considerations: Expected to be stable under typical food processing conditions, but specific data on heat, pH, and oxidation stability is not available.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

Fragrance Families and Product Types: Could be used in oriental or woody fragrance families due to its potential aromatic qualities.
Functional Role: Likely serves as a trace realism note or a modifier.
Typical Concentration Ranges: Not clearly reported; formulators should use industry-typical practices.
Volatility and Top/Middle/Base Contribution: Likely contributes to the middle or base notes due to its molecular weight and structure.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

United States (FDA / FEMA GRAS): Not explicitly listed as GRAS.
European Union (Reg. (EC) No 1334/2008; FL number status): Not listed.
United Kingdom: Follows EU regulations post-Brexit; not specifically listed.
Asia (Japan, China, ASEAN): No specific data available; formulators should consult local regulations.
Latin America (e.g., Brazil, MERCOSUR): No specific data available; consult local regulatory frameworks.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

Oral Exposure: Data not found; formulators should consider typical safety margins and consult toxicology experts.
Dermal Exposure: No specific irritation or sensitization data available; IFRA guidelines should be consulted for fragrance use.
Inhalation Exposure: Volatility suggests potential for inhalation exposure; occupational safety measures should be considered.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Why This Material is Valuable: Offers unique aromatic qualities due to its complex structure.
Typical Synergies: May blend well with other aromatic or spicy compounds.
Common Formulation Pitfalls: Overuse can lead to overpowering notes; balance is key.
Situations Where It is Frequently Over- or Under-used: Often under-utilized due to lack of specific sensory data.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

Well-Established Data: Limited due to the synthetic nature and lack of widespread use.
Industry-Typical but Undocumented Practices: Formulators rely on structural analogs for guidance.
Known Data Gaps or Regulatory Ambiguities: Lack of specific sensory and regulatory data.

Citation hooks: FlavScents

QA Check

All required sections 1–9 are present
“Citation hooks:” line is present under each section
Flavor section includes ppm ranges (not available, noted as data not found)
Toxicology section covers oral, dermal, inhalation
Regulatory section mentions US, EU, UK, Asia, Latin America
If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-10-15 20:00:46 GMT (p2)

Suppliers

No suppliers are currently related to this material.

Become a FlavScents Supplier