AInsights Entry for Ambroxan (CAS: 6790-58-5)

1. Identity & Chemical Information

• Common Name(s): Ambroxan
• IUPAC Name: (3aS,5S,9aS,9bS)-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan
• CAS Number: 6790-58-5
• FEMA Number: 3685
• Other Identifiers: FL No. 09.037
• Molecular Formula: C16H28O
• Molecular Weight: 236.39 g/mol
• Functional Groups and Structure–Odor Relevance: Ambroxan is a bicyclic furan derivative with a distinctive musky odor. Its structure contributes to its high stability and long-lasting scent, making it a valuable component in perfumery.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Ambroxan is renowned for its rich, musky, and slightly woody aroma. It is often described as having a warm, ambergris-like scent with a subtle sweetness. The intensity of ambroxan is moderate to strong, and it exhibits excellent diffusion properties. It is primarily used as an impact note in fragrance compositions, providing depth and longevity. The odor threshold of ambroxan is relatively low, allowing it to be perceived at minimal concentrations.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Ambroxan is not found naturally in its pure form but is derived from sclareol, a diterpene alcohol found in clary sage (Salvia sclarea). The transformation involves a series of chemical reactions, including oxidation and cyclization. Ambroxan's synthetic origin does not preclude its use in "natural fragrance" formulations, provided it is derived from natural precursors.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Ambroxan is less commonly used in flavors compared to fragrances, but it can impart a subtle musky note to certain flavor profiles, particularly in luxury or niche products. It may be used in flavor categories such as confectionery and beverages, where it acts as a background modifier. Typical use levels in food are low, often below 1 ppm, due to its potent aroma. Ambroxan is stable under a variety of conditions, including heat and acidic environments, making it versatile in formulation.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

Ambroxan is a staple in the fragrance industry, used across various fragrance families, including woody, oriental, and fougère. It serves as a base note, providing longevity and a musky depth to compositions. Typical concentrations in perfumes range from 0.1% to 5%, depending on the desired intensity and character. Its low volatility ensures a lasting presence, contributing significantly to the fragrance's dry-down phase.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Ambroxan is recognized as GRAS by FEMA for flavor use.
• European Union: Listed under Regulation (EC) No 1334/2008 with an assigned FL number.
• United Kingdom: Regulatory status aligns with the EU post-Brexit.
• Asia: Generally accepted in Japan and China, though specific regulations may vary.
• Latin America: Accepted in Brazil and MERCOSUR countries, with harmonized assumptions across the region.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Ambroxan has a high margin of safety for oral exposure, with no specific ADI established. It is used at low concentrations in flavors.
• Dermal Exposure: Generally considered safe for dermal application in fragrances, with no significant irritation or sensitization reported. IFRA guidelines should be consulted for specific use limits.
• Inhalation Exposure: Low volatility reduces inhalation risks, though occupational exposure should be monitored in manufacturing settings.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Ambroxan is valued for its ability to enhance the longevity and depth of fragrance compositions. It synergizes well with other musky and woody notes, providing a smooth, rounded finish. Formulators should be cautious of overuse, as its potent aroma can dominate a blend. It is often underutilized in flavor applications, where its subtle musky note can add complexity.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

Data on ambroxan is well-established, with comprehensive sensory and regulatory information available. Industry practices are well-documented, though specific use levels in flavors may vary. No significant data gaps or regulatory ambiguities are noted.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-08-08 03:53:27 GMT (p2)