FlavScents AInsights Entry for Sandal Cyclopropane (CAS: 198404-98-7)

1. Identity & Chemical Information

• Common Name(s): Sandal Cyclopropane
• IUPAC Name: 1-(2,2,3-Trimethyl-3-cyclopropylpropyl)-2-methylpropyl acetate
• CAS Number: 198404-98-7
• FEMA Number: Not available
• Other Identifiers: Not available
• Molecular Formula: C15H28O2
• Molecular Weight: 240.39 g/mol

Sandal cyclopropane is a synthetic compound characterized by its cyclopropane ring, which contributes to its unique odor profile. The presence of acetate and methyl groups influences its volatility and sensory characteristics, making it a valuable component in fragrance formulations.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Sandal cyclopropane is known for its rich, woody, and creamy sandalwood-like aroma. It is often described as having a smooth, soft, and slightly sweet character with moderate intensity and good diffusion. The compound is typically used as an impact note in fragrance compositions, providing depth and warmth.

Odor thresholds for sandal cyclopropane are not clearly reported in the literature. However, its role as a prominent note in sandalwood accords suggests a relatively low threshold, allowing it to impart a noticeable effect even at low concentrations.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Sandal cyclopropane is a synthetic compound and does not occur naturally. It is produced through chemical synthesis, often involving the cyclopropanation of suitable precursors. As a synthetic analog of natural sandalwood components, it is used to replicate the desirable characteristics of natural sandalwood oil in fragrance applications.

The compound's synthetic nature means it does not qualify for "natural flavor" or "natural fragrance" designations, which are typically reserved for materials derived from natural sources.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Sandal cyclopropane is not commonly used in flavor applications due to its primary association with fragrance. However, when used, it may contribute a subtle woody note to certain flavor profiles, particularly in complex formulations where a hint of sandalwood is desired.

Typical use levels in flavors are not well-documented, but industry practice suggests that if used, concentrations would be very low, likely in the range of 0.1-1 ppm in finished products, to avoid overpowering other flavor notes.

Stability considerations include moderate resistance to heat and oxidation, making it suitable for use in a variety of flavor systems.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

Sandal cyclopropane is widely used in the fragrance industry, particularly in the creation of sandalwood accords. It is a key component in woody, oriental, and chypre fragrance families. Its role as an impact note and modifier makes it valuable for adding depth and warmth to compositions.

Typical concentration ranges in fragrances vary, with usage levels often between 0.5% and 5% depending on the desired intensity and the complexity of the fragrance. It contributes primarily to the base notes due to its moderate volatility.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Sandal cyclopropane is not specifically listed by FEMA as GRAS for flavor use. Its use in fragrances is subject to general safety and labeling regulations.
• European Union: Not explicitly listed under Regulation (EC) No 1334/2008 for flavor use. Fragrance use is regulated under the EU Cosmetics Regulation.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Regulatory status varies; not specifically listed in Japan or China for flavor use. Fragrance use is subject to local cosmetic regulations.
• Latin America: Generally follows international guidelines; specific listings not found.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Limited data available; not typically used in flavors. No ADI or MSDI established.
• Dermal Exposure: Generally considered safe for use in fragrances at typical concentrations. No significant irritation or sensitization reported.
• Inhalation Exposure: Moderate volatility suggests potential for inhalation exposure in occupational settings, but no specific occupational exposure limits found.

Risk profiles differ between food and fragrance applications, with fragrance use being more common and better characterized.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Sandal cyclopropane is valued for its ability to impart a rich, woody character reminiscent of natural sandalwood. It synergizes well with other woody and oriental notes, enhancing the overall depth and complexity of a fragrance.

Common pitfalls include overuse, which can lead to an overpowering scent profile. It is often under-used in formulations seeking a subtle sandalwood nuance.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

Data on sandal cyclopropane is well-established in the context of fragrance use, with industry-typical practices documented. However, there are gaps in flavor use data and specific regulatory listings, reflecting its primary role in perfumery.

Citation hooks: FlavScents

QA Check

• All required sections 1-9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-06-22 18:50:32 GMT (p2)