FlavScents AInsights Entry: Stearamidopropyl Trimonium Methosulfate (CAS: 19277-88-4)

1. Identity & Chemical Information

• Common Name(s): Stearamidopropyl Trimonium Methosulfate
• IUPAC Name: N-[3-(Dimethylamino)propyl]octadecanamide methosulfate
• CAS Number: 19277-88-4
• FEMA Number: Not applicable
• Other Identifiers: Not applicable
• Molecular Formula: C24H52N2O4S
• Molecular Weight: 464.75 g/mol

Stearamidopropyl trimonium methosulfate is a quaternary ammonium compound, characterized by its long hydrophobic tail derived from stearic acid and a hydrophilic quaternary ammonium head. This structure is crucial for its function as a conditioning agent in personal care products, where it imparts a soft, silky feel to hair and skin.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Stearamidopropyl trimonium methosulfate is not typically used for its sensory properties in flavors or fragrances. It is primarily valued for its functional properties in formulations, such as improving texture and feel. As such, it does not have significant odor or flavor descriptors associated with its use.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Stearamidopropyl trimonium methosulfate is a synthetic compound and does not occur naturally. It is typically produced through the reaction of stearic acid with dimethylaminopropylamine, followed by quaternization with methyl sulfate. This synthetic origin means it does not qualify for "natural flavor" or "natural fragrance" designations.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Stearamidopropyl trimonium methosulfate is not commonly used in flavor applications due to its primary role as a conditioning agent in personal care products. Therefore, specific flavor categories, applications, and use levels in ppm are not applicable. Its stability under various conditions such as heat and pH is more relevant to its use in non-flavor applications.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance formulations, stearamidopropyl trimonium methosulfate is used for its functional properties rather than its scent. It acts as a conditioning agent, enhancing the feel of the product on the skin or hair. It is typically used in low concentrations, often less than 1%, and does not contribute significantly to the volatility or scent profile of a fragrance.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not listed as a FEMA GRAS substance for flavor use. Its use in personal care products is regulated by the FDA.
• European Union: Not listed under Regulation (EC) No 1334/2008 for flavor use. It is regulated under cosmetic regulations.
• United Kingdom: Follows EU regulations post-Brexit for cosmetic use.
• Asia: Regulations vary; commonly used in personal care products in Japan and China.
• Latin America: Usage in personal care products is generally accepted, but specific regulations may vary by country.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Not applicable for flavor use; no ADI or MSDI established.
• Dermal Exposure: Generally considered safe for use in personal care products. It is not a known irritant or sensitizer at typical use levels.
• Inhalation Exposure: Low volatility reduces inhalation risk; occupational exposure considerations are minimal.

The risk profile is primarily relevant to its use in personal care products rather than food or fragrance applications.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Stearamidopropyl trimonium methosulfate is valued for its ability to improve the texture and feel of personal care products. It synergizes well with other conditioning agents and is often used in hair conditioners and skin creams. Formulators should be aware of its potential to build up on hair with excessive use, which can lead to a greasy feel.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on stearamidopropyl trimonium methosulfate is well-established in the context of personal care applications. However, its use in flavors and fragrances is limited, leading to gaps in sensory and flavor-related data. Regulatory information is robust for cosmetic use but less so for other applications.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges (not applicable)
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-03-02 17:20:07 GMT (p2)