FlavScents AInsights Entry: Calcium cis-1,2-cyclohexanedicarboxylate (CAS: 491589-22-1)

1. Identity & Chemical Information

• Common Name(s): Calcium cis-1,2-cyclohexanedicarboxylate
• IUPAC Name: Calcium bis(cyclohexane-1,2-dicarboxylate)
• CAS Number: 491589-22-1
• FEMA Number: Not applicable
• Other Identifiers: Not applicable
• Molecular Formula: C14H18CaO8
• Molecular Weight: 354.37 g/mol

Calcium cis-1,2-cyclohexanedicarboxylate is a calcium salt of cis-1,2-cyclohexanedicarboxylic acid. The compound features carboxylate functional groups, which can influence its solubility and reactivity. The cyclohexane ring structure may contribute to its stability and potential interactions in formulations.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Calcium cis-1,2-cyclohexanedicarboxylate is not typically associated with a distinct odor or flavor profile, as it is primarily used for its functional properties rather than sensory characteristics. Its role in formulations is more about modifying texture or stability rather than imparting a specific taste or aroma.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

This compound is not naturally occurring and is typically synthesized for industrial use. It is produced through the neutralization of cis-1,2-cyclohexanedicarboxylic acid with calcium hydroxide or calcium carbonate. As a synthetic compound, it does not qualify for "natural flavor" or "natural fragrance" designations.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Calcium cis-1,2-cyclohexanedicarboxylate is not commonly used as a flavoring agent due to its lack of sensory impact. However, it may be used in flavor systems as a stabilizer or to modify the texture of certain products. Typical use levels in food are not well-documented, but it is generally used at low concentrations to avoid altering the flavor profile of the product.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance applications, calcium cis-1,2-cyclohexanedicarboxylate is not used for its scent but may be included as a stabilizing agent or to adjust the viscosity of a formulation. Its contribution to the fragrance profile is negligible, and it is typically used in trace amounts.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not specifically listed as GRAS by FEMA; usage would be subject to general safety and regulatory guidelines.
• European Union: Not listed under Regulation (EC) No 1334/2008; usage would require compliance with general safety standards.
• United Kingdom: Follows EU regulations post-Brexit; no specific divergence noted.
• Asia: No specific regulations found; general safety standards apply.
• Latin America: No specific regulations found; general safety standards apply.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Data not found for specific ADI or MSDI values. General safety practices suggest using minimal effective concentrations.
• Dermal Exposure: Not known to cause irritation or sensitization; however, IFRA guidelines should be consulted for specific product types.
• Inhalation Exposure: Low volatility reduces inhalation risk; occupational exposure should be minimal.

Risk profiles do not significantly differ between food and fragrance applications, given its functional rather than sensory role.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Calcium cis-1,2-cyclohexanedicarboxylate is valued for its stabilizing properties in both flavor and fragrance formulations. It can enhance the texture and stability of products without impacting sensory characteristics. Formulators should be cautious of overuse, which could lead to unwanted textural changes.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on calcium cis-1,2-cyclohexanedicarboxylate is limited, particularly regarding its sensory and toxicological profiles. Most information is derived from industry practices and general chemical knowledge. Regulatory and safety data are not comprehensive, highlighting the need for cautious application.

Citation hooks: FlavScents

QA Check

• All required sections 1-9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges (not applicable due to lack of data)
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-03-06 09:20:55 GMT (p2)